Custom Peptides
Cayman Chemical LestaurtInIb 10mg
A staurosporine analog that potently inhibits JAK2 kinase (IC50 = 1 nM) and downstream targets STAT5 (IC50 = 10-30 nM) and STAT3 in a human erythroleukemic cell line expressing the JAK2V617F mutation; potently inhibits the epigenetic kinase PRK1 (PKN1) in vitro (IC50 = 8.6 nM)
Cayman Chemical 3 4-MDPAhydrochlorIde 10mg
A lesser known psychoactive substituted amphetamine of the phenethylamine class that has been used as an internal standard for qualitative and quantitative analyses of hallucinogenic designer drugs in biological samples; intended for forensic and research purposes
Cayman Chemical BIlIverdIntechnIcal grade 10mg
A bile pigment; formed via oxidative catabolism of heme by HO-1; has antioxidant activity in ORAC and TEAC assays at >0.5 µM
Cayman Chemical DIoctnoyl Glycol 10mg
A DGK inhibitor (Ki = 58 μM); reduces basal and thrombin-stimulated phosphatidic acid levels in washed isolated human platelets at 30, 100, and 500 μM
Cayman Chemical 6 7-EpoxybergamotIn 10mg
A potent CYP3A4 inhibitor (IC50s = 0.30 ppm in a cell-free assay, 0.33 µM in HL7 human liver cells, and 0.22 µM in S9 human intestine cells); inhibits the transport of talinolol, a P-gp/ABCB1 transporter substrate, across Caco-2 cell monolayers (IC50 = 0.7 µM)
Cayman Chemical ALC-0315 nalogous-1 10mg
An ALC-0315 derivative; has been used in the synthesis of ionizable cationic lipids used in the generation of LNPs
Cayman Chemical TatsyndegrontrIfluoroace 10mg
An α-synuclein knockdown peptide; binds to recombinant α-synuclein in a peptide-protein binding assay and reduces α-synuclein levels in primary rat cortical neuron cultures; reduces brain α-synuclein levels in M38 transgenic mice that overexpress human A53T mutant α-synuclein at 40 mg/kg; reduces phosphorylated α-synuclein levels in the substantia nigra and the pons, as well as neuroinflammation in a mouse model of spreading synucleinopathy; protects against dopaminergic neuron loss and rescues motor deficits in a mouse model of MPTP-induced Parkinson’s disease at 6 µmol/kg, i.p.
Cayman Chemical 16phenoxy ttrnor PROSGla 10mg
16-phenoxy tertanor PGF2α is a metabolically stable analog of PGF2α. It binds to the FP receptor on ovine luteal cells with much greater affinity (440%) than PGF2α.{2058}
Cayman Chemical TrovafloxacInmesylate 10mg
A broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in bacteria by blocking the activity of topoisomerase IV (IC50 = 3.02 UG/ml) and DNA gyrase (IC50 = 7.13 UG/ml)
Cayman Chemical MCOPPBhydroCLOrID hydrate 10mg
A potent, selective agonist for the nociceptin receptor (pKi = 10.1, EC50 = 0.39 nM); produces potent anxiolytic effects in rodents at 10 mg/kg, p.o. without inhibiting memory or motor function or inducing sedative side effects
Cayman Chemical OmecamtIv MecarbIl 10mg
A cardiac myosin ATPase activator (AC40 = 0.58 µM for the bovine enzyme); increases fractional shortening in rats in a dose-dependent manner
Cayman Chemical BInImetInIb 10mg
A MEK1 and MEK2 inhibitor (IC50s = 1.8 and 0.92 nM, respectively); selective for MEK1/2 over RAF/MEK/ERK pathway kinases at 10 µM; reduces cell growth in HT-29, COLO 205, and LoVo cells (IC50s = 0.48, 0.52, and 2.2 nM, respectively); reduces tumor volume in a COLO 205 mouse xenograft model at 0.3 mg/kg
Cayman Chemical 4chloro2 5DMAhydrochlorI 10mg
An analytical reference standard categorized as an amphetamine; has a high addictive liability in rodents; has been associated with fatality; has been detected in blotter papers seized by law enforcement; intended for research and forensic applications
Cayman Chemical 7-hydroxy Methotrexate 10mg
A metabolite of methotrexate; does not inhibit thymidylate synthase in isolated human acute myeloid and acute lymphoblastic leukemia cells; has a maximum tolerated dose of 0.1 g/kg in rats